眠れない・寝つきが悪いとき

A Randomized, Placebo-controlled Study to Investigate the Efficacy and Safety of Circadin® to Alleviate Sleep Disturbances in Children With Neurodevelopmental Disabilities

• 参加者 125人
• 神経発達障害を持つ小児

原文よりSleep Latency (minutes) derived from Sleep and Nap Diary following 13 weeks of double-blind treatment with Circadin 2/5 mg minitabs versus placebo.

Meta-analysis: melatonin for the treatment of primary sleep disorders.

• 参加者 1,683人
• 一次性睡眠障害の成人および小児 1683名

原文よりMelatonin demonstrated significant efficacy in reducing sleep latency (weighted mean difference (WMD) = 7.06 minutes [95% CI 4.37 to 9.75], Z = 5.15, p<0.001)

The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial.

• 参加者 203人
• ICU入室の成人患者 203名

原文よりBased on the RCSQ results, sleep quality was assessed to be better in the melatonin group than that in the placebo group with a mean (SD) of 69.7 (21.2) and 60.7 (26.3), respectively (p = 0.029).

Meta-analysis: melatonin for the treatment of primary sleep disorders.

• 参加者 1,683人
• 一次性睡眠障害の成人および小児 1683名

原文よりOverall sleep quality was significantly improved in subjects taking melatonin (standardized mean difference = 0.22 [95% CI: 0.12 to 0.32], Z = 4.52, p<0.001) compared to placebo.

Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality.

• 参加者 20人

原文よりThere were significant increases in time in bed, total sleep time and sleep efficiency total (P < 0.05) with cherry juice supplementation.

Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews.

原文よりDespite heterogeneity in review methods and outcome definitions, the direction of evidence consistently favored melatonin over placebo.

Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.

• 参加者 516人
• 手術を受けた成人患者 (516名)

原文よりA random-effects meta-analysis showed that melatonin did not improve sleep quality measured by VAS compared with placebo (mean difference, -0.75 mm; 95% confidence interval, -4.86 to 3.35), with low heterogeneity (I2, 5%).

Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study.

• 参加者 100人
• 慢性的なストレスを抱える健康な成人 100名

原文よりImprovements in daytime dysfunction due to sleepiness (Pittsburgh Sleep Quality Index-7 component score) were reported on Day 28, and were significant on Day 56 (p < 0.001).

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.

• 参加者 30人
• 精神疾患のない健康な成人 30名
• 200 mg/日 4週間

原文よりThe PSQI subscale scores for sleep latency, sleep disturbance, and use of sleep medication reduced after L-theanine administration, compared to the placebo administration (all p < 0.05).

Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months.

• 参加者 99人
• 抹茶2g/日 12ヶ月間

原文よりThe present study suggests regular consumption of matcha could improve emotional perception and sleep quality in older adults with mild cognitive decline.

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.

原文よりGABA/l-theanine mixture has a positive synergistic effect on sleep quality and duration as compared to the GABA or l-theanine alone.

The sleep-enhancing effect of valerian inhalation and sleep-shortening effect of lemon inhalation.

• ラット

原文よりa significant shortening in sleep latency and a significant prolonging in total sleep time were observed with valerian inhalation

Critical evaluation of the effect of valerian extract on sleep structure and sleep quality.

• 参加者 16人
• 精神生理学的な不眠症の患者 16名

原文よりIn comparison with the placebo, slow-wave sleep latency was reduced after administration of valerian (21.3 vs. 13.5 min respectively, p<0.05).

Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.

• 参加者 6,894人
• 7-80歳の被験者を含む多様な研究対象 (n=6,894)

原文よりIn conclusion, valerian could be a safe and effective herb to promote sleep and prevent associated disorders.

Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.

• 参加者 72人
• 睡眠の悩みを持つ成人 72名

原文よりVE supplementation significantly improved various subjective and objective parameters of sleep in young subjects with mild insomnia symptoms, such as overall sleep quality, sleep latency, sleep efficiency, and total sleep time.

A Quasi Experimental Study to Assess the Effectiveness of Hot Water Foot Bath Therapy on Quality of Sleep among the Elderly in Selected Old Age Home, Agartala, Tripura West

• 参加者 40人

原文よりThe finding of the study revealed that paired ‘t’ test between pretest and post test score in experimental group showed significant increase in quality of sleep (tcal = 15.86, pcal = 0.53, pcal = 5.09, p2 = 5.714, p< 0.05) and there was no significant association between the pre-test quality of sleep scores with remaining demographic variables.

A Study to Assess the Effect of Hot Water Foot Bath Therapy on the Quality of Sleep among Elderly Patients Admitted in Hanagal Shree Kumareshwar Hospital and Research Centre, Bagalkot

• 参加者 50人
• 入院患者および外来の高齢者 50名

原文よりH1 is accepted hence hot water foot bath therapy was effective.