夜中に目が覚めるとき

Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomized, Repeated-Measures, Double-Blind Deception Study.

• 参加者 16人
• 24歳前後の男女 16名
• 3日間

原文よりThe intervention trial reduced sleep onset latency (-24 ± 25 min; P = 0.002), increased total sleep time (22 ± 32 min; P = 0.01), and increased sleep efficiency (2.4% ± 3.9%; P = 0.03), while also reducing morning sleepiness ( P = 0.02).

Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.

• 参加者 80人
• 35-55歳の睡眠問題のある成人 80名
• 1g/日 21日間

原文よりThe MgT group maintained good sleep quality and daytime functioning, while placebo declined.

The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.

• 参加者 100人
• 睡眠に不満を感じている18〜45歳の成人 100名
• Magtein® 2g/日 6週間

原文よりBased on self-report measures, there was a greater improvement in sleep-related impairment (p = 0.043), but no group differences in changes in sleep disturbances (p = 0.316), restorative sleep (p = 0.439), or general wellbeing (p = 0.436); although in a subset of participants with more severe sleep-related problems, group differences in sleep-disturbances were identified (p = 0.031).

The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.

• 参加者 46人

原文よりSupplementation of magnesium appears to improve subjective measures of insomnia such as ISI score, sleep efficiency, sleep time and sleep onset latency, early morning awakening, and likewise, insomnia objective measures such as concentration of serum renin, melatonin, and serum cortisol, in elderly people.

Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.

• 不安や不眠の症状がある人々（個別研究は個別に対象者が違い、異質性あり）

原文よりThe majority of included studies demonstrated improvement in at least one sleep- or anxiety-related parameter. Five out of eight sleep-related studies reported improvements in sleep parameters, while two studies reported no improvements, and one reported mixed results.

Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.

• 参加者 3,964人
• CARDIA研究の参加者 3,964名
• 食事およびサプリメントによる摂取量 (ベースラインから20年間の追跡)

原文よりAfter adjustment for potential confounders, Mg intake was borderline associated with better sleep quality [highest quartile (Q4) vs. intake quartile (Q1): odds ratio (OR) = 1.23; 95% CI = 0.999, 1.50, ptrend = 0.051].

New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.

• 不眠傾向の成人

原文よりGlycine ingestion before bedtime significantly ameliorated subjective sleep quality in individuals with insomniac tendencies.

The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.

• ラット (rats)

原文よりshortened NREM sleep latency with a simultaneous decrease in core temperature.

Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomized, Repeated-Measures, Double-Blind Deception Study.

• 参加者 16人
• 24歳前後の男女 16名
• 3日間

原文よりThe intervention trial reduced sleep onset latency (-24 ± 25 min; P = 0.002), increased total sleep time (22 ± 32 min; P = 0.01), and increased sleep efficiency (2.4% ± 3.9%; P = 0.03), while also reducing morning sleepiness ( P = 0.02).

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.

• 睡眠制限を受けた健康な被験者
• 3g/日 3日間

原文よりIn subjects given glycine, the VAS data showed a significant reduction in fatigue and a tendency toward reduced sleepiness. These observations were also found via the questionnaire, indicating that glycine improves daytime sleepiness and fatigue induced by acute sleep restriction.

New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.

• 不眠傾向の成人
• 就寝前の経口投与

原文よりGlycine ingestion before bedtime significantly ameliorated subjective sleep quality in individuals with insomniac tendencies.

The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.

• ラット (rats)

原文よりThese data suggest that exogenous glycine promotes sleep via peripheral vasodilatation through the activation of NMDA receptors in the SCN shell.

New Functions and Potential Applications of Amino Acids.

原文よりGlycine can be ingested for good night's sleep: glycine ingestion before bedtime significantly improved subjective sleep quality.

The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.

• 睡眠制限を受けた健康な被験者
• 3g/日 3日間

原文よりIn subjects given glycine, the VAS data showed a significant reduction in fatigue and a tendency toward reduced sleepiness.