Sleep / melatonin
melatonin
Evidence for sleep, scored from the published research.
sleep onset latency
promising79/100 Evidence ScoreConfidence: high2 studies1 RCT
Multiple human studies report a positive effect.
- 2 human studies (1,808 participants total)
- Studies point in broadly the same direction
References (2)
- A Randomized, Placebo-controlled Study to Investigate the Efficacy and Safety of Circadin® to Alleviate Sleep Disturbances in Children With Neurodevelopmental Disabilitiesrandomized controlled trial (RCT) · 2013
- Meta-analysis: melatonin for the treatment of primary sleep disorders.meta-analysis · PloS one · 2013
sleep quality
promising60/100 Evidence ScoreConfidence: moderate5 studies2 RCTs
Multiple human studies report a positive effect.
- 5 human studies (2,422 participants across the 4 with counts recorded; 1 review/meta-analysis not counted individually)
- Studies disagree with each other
- Still unknown: few longer-duration studies
References (5)
- The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial.randomized controlled trial (RCT) · Critical care medicine · 2020
- Meta-analysis: melatonin for the treatment of primary sleep disorders.meta-analysis · PloS one · 2013
- Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality.randomized controlled trial (RCT) · European journal of nutrition · 2012
- Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews.systematic review · Journal of clinical pharmacology · 2026
- Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.meta-analysis · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
Evidence Scores are computed mechanically from the published research (PubMed / Semantic Scholar / OpenAlex): study design, participant numbers, and consistency across studies. An LLM is used only to extract study data, never to decide a score.
This is research-based information, not medical advice, and not a diagnosis. Consult a qualified professional about your own situation.