- Research reports indicate a positive effect on sleep quality.
- The evidence score is 59, indicating moderate reliability.
- There is research data on healthy workers experiencing stress and on people with specific conditions.
Ornithine is a type of amino acid.
It is generally taken in contexts such as nutritional supplementation.
There are reports that taking ornithine may cause changes in sleep quality.
In a small-scale study involving 52 participants experiencing stress and fatigue, sleep quality was shown to improve. This study targeted 52 healthy Japanese adults. In other words, ornithine may be related to sleep quality even in situations where people are experiencing daily fatigue or stress.
This study used a randomized controlled trial (a reliable research method in which participants are randomly assigned to compare effects). Methods that determine target groups in advance and then divide them by condition in this way are considered to have high objectivity. In addition, as a result of a survey conducted over a 56-day period, reports also included suppression of feelings of anger, in addition to sleep quality.
Ornithine has been used in research not only on healthy people but also on people in specific conditions.
In a study involving 193 participants, changes were reported in symptoms such as sleep quality and fatigue. This study was conducted on people with hepatic encephalopathy (a condition in which reduced liver function affects the brain) due to cirrhosis. Specifically, improvements were suggested in areas such as fatigability and lack of concentration, alongside sleep quality.
The design of this study includes a cohort study (a survey method that continuously observes a specific group to see changes over time). It was also conducted using an open-label (a trial in which participants know what they are taking) and prospective (a survey format that follows the passage of time going forward) method.
A total of 2 studies on ornithine have been confirmed. Of the two cases cited here, one is a randomized controlled trial, and the other is an observational study. Therefore, the overall evidence score (a numerical representation of the quality of the research and the certainty of the results) is 59.
This score indicates moderate reliability, but it is still difficult to judge everything based on this alone. Depending on the content of the research, some individuals may not experience an effect, and it may not suit everyone. Since this research data includes studies of people with specific diseases as well as observational studies that tracked progress, caution is needed in how the results are interpreted.
| Study | Design | Number of Participants | Duration | Main Result |
|---|---|---|---|---|
| Nutrition journal (2014, PMID:24889392) | Randomized controlled trial (RCT) | 52 | 56 days | A positive effect was reported |
| Clinical drug investigation (2011, PMID:21208014) | Cohort study | 191 | 56 days | A positive effect was reported |
The subjects of the research include 52 healthy Japanese adults experiencing stress and fatigue, and 193 patients with hepatic encephalopathy due to cirrhosis.
Research has been conducted on both healthy people and people with specific diseases. This can serve as material for checking against your own situation.
There are 2 studies.
The study designs include cohort studies in addition to randomized controlled trials (RCTs).
The reliability of the research results is considered moderate.
What effect is ornithine reported to have on sleep quality?
Research has reported a positive effect on sleep quality. This includes 2 studies.
Has ornithine been studied even in cases of stress?
There is a study of healthy Japanese adults experiencing stress and fatigue. The study reported an effect on sleep quality.
Is ornithine studied even in the presence of disease?
There is a study of patients with hepatic encephalopathy due to cirrhosis. The study includes reports on symptoms such as sleep quality and fatigue.
Two studies suggest that ornithine may have a positive effect on sleep quality. However, the evidence score is 59, indicating moderate reliability. Since this data involves a limited number of participants and also includes observational research, results may vary depending on an individual's condition.
Why not check whether your sleep habits suit you with the self-check assessment?